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Key References


  • Siltuximab for multicentric Castleman’s disease: a randomised, double-blind, placebo-controlled trial.
    Van Rhee F, Wong RS, Munshi N, Rossi JF, Ke XY, Fossa A, et al.
    Lancet Oncol. 2014;15(9):966-74.


  • International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic
    multicentric Castleman disease.

    Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, et al.
    Blood. 2017;129(12):1646-57.



  • International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease.
    Van Rhee F, Voorhees R, Dispenzieri A, Fosså A, Srkalovic G, Ide M, et al.
    Blood. 2018;132(15): 2115-24.


  • Newly diagnosed and previously treated multicentric Castleman disease respond equally to siltuximab.
    Van Rhee F, Rossi JF, Simpson D, et al.
    British Journal of Haematology. 2020 Oct. DOI: 10.1111/bjh.17177.




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