To meet the major criteria for iMCD diagnosis, patients must have grade ≥2 ‘hypervascular’ or ‘plasmacytic’
lymph node histopathyology – or a mix of both (Figure 2, Table 1).1
Figure 2: iMCD lymph node histopathology
Table 1: Spectrum of lymph node histopathology for iMCD diagnoses1
Images below are examples of the respective grades for each histopathological feature (Figure 3).
Figure 3: Grades for each histopathological feature seen in iMCD
Grade 2 or 3 for either regressed GCs or plasmacytosis is needed to meet the major criteria for iMCD diagnosis (other features consistent with the iMCD histologic spectrum should also be present)
The above images are examples of the respective grades for each histopathologic feature. Deidentified lymph node slides were prestained with hematoxylin and eosin. Bars represent 500 mm (A,D), 80 mm (B), 200 mm (C), 60 mm (E).
Adapted from Fajgenbaum DC et al.1